A dual-emissive supramolecular sensor for fast and ratiometric determination of carprofen in meat

Carprofen (CPF) is a non-steroidal anti-inflammatory drug that has been widely used in livestock for the treatment of fever and inflammation. Yet the massive use of CPF comes at the cost of its residue ubiquitous in the environment thus leading to a huge risk to human health. Therefore, development of a convenient analytical method for monitoring CPF is of considerable importance. In this study, a dual-emissive supramolecular sensor was facilely constructed using bovine serum albumin as the host and an environmentally sensitive dye as the guest. This sensor, for the first time, successfully realized the fluorescent detection of CPF with a rapid response, high sensitivity and selectivity. More importantly, this sensor exhibited a very unique ratiometric response to CPF, which endowed this method with satisfactory detection accuracy for food analysis. To the best of our knowledge, this is the first fluorescent method for fast determination of CPF in food.