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MicroRNAs as important players in regulating cancer through PTEN/PI3K/AKT signalling pathways

Sushmaa Chandralekha Selvakumar1, K Auxzilia Preethi1, Durairaj Sekar1

  • 1RNA Biology Lab, Centre for Cellular and Molecular Research, Saveetha Dental College & Hospitals, Saveetha Institute of Medical & Technical Sciences (SIMATS), Saveetha University, Chennai 600077, India.

Biochimica Et Biophysica Acta. Reviews on Cancer
|May 4, 2023
PubMed

Insights

This review explores microRNAs (miRNAs) that regulate the PTEN/PI3K/AKT pathway, a key player in cancer development. Understanding these miRNA-pathway interactions can reveal new therapeutic targets for cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer remains a leading global cause of mortality.
  • Current cancer therapies face challenges due to lack of specificity and understanding of molecular mechanisms.
  • The PTEN/PI3K/AKT signaling pathway is crucial in cell proliferation, apoptosis, and tumor growth.

Purpose of the Study:

  • To review the role of microRNAs (miRNAs) in regulating the PTEN/PI3K/AKT pathway.
  • To identify novel therapeutic strategies for cancer based on miRNA regulation of this pathway.

Main Methods:

  • Literature review focusing on studies investigating miRNAs and the PTEN/PI3K/AKT axis in carcinogenesis.
  • Analysis of the downstream effects of the PTEN/PI3K/AKT pathway, including malignancy, metastasis, and chemoresistance.

Main Results:

  • Identified various microRNAs (miRNAs) that significantly influence the PTEN/PI3K/AKT pathway.
  • Highlighted the involvement of these miRNAs in the pathogenesis of diverse cancers.
  • Demonstrated the potential of miRNAs in modulating tumor growth, metastasis, and chemoresistance via the PTEN/PI3K/AKT axis.

Conclusions:

  • MicroRNAs are critical regulators of the PTEN/PI3K/AKT pathway in cancer.
  • Targeting specific miRNAs offers a promising avenue for developing novel, targeted cancer therapeutics.
  • Further research into miRNA-PTEN/PI3K/AKT interactions can advance cancer treatment strategies.
Keywords:
BiomarkersCancerGene regulationMolecular mechanismsSignalling pathwaysTherapeutic targetmicroRNAs

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