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Thromboprophylaxis for Coagulopathy Related to COVID-19 in Pediatrics: A Narrative Review

Hadi Sahrai1, Mahdi Hemmati-Ghavshough1, Marzieh Shahrabi2

  • 1Student research committee, Tabriz University of Medical Sciences, Tabriz, Iran.

Paediatric Drugs
|May 4, 2023
PubMed

Insights

COVID-19 complications like multisystem inflammatory syndrome in children (MIS-C) can cause blood clotting issues. Anticoagulant prophylaxis may reduce these thrombotic events, but more pediatric research is needed.

Area of Science:

  • Pediatric critical care medicine
  • Hematology
  • Infectious diseases

Background:

  • COVID-19 affects multiple organs beyond the respiratory system.
  • Multisystem inflammatory syndrome in children (MIS-C) is a serious COVID-19 complication impacting the pediatric vascular system.
  • MIS-C can lead to various coagulopathies in children.

Purpose of the Study:

  • To review existing literature on thromboprophylaxis use in children with MIS-C.
  • To understand the role of immune responses in triggering thrombotic events in MIS-C.
  • To assess current evidence regarding anticoagulant use in pediatric MIS-C.

Main Methods:

  • Literature review of articles discussing thromboprophylaxis in MIS-C.
  • Analysis of factors influencing thrombotic event initiation.
  • Examination of studies correlating D-dimer levels and anticoagulant prophylaxis.

Main Results:

  • Immune system responses are implicated in initiating thrombotic events.
  • Anticoagulant prophylaxis initiation is guided by patient condition and D-dimer levels.
  • Evidence suggests anticoagulant prophylaxis can decrease thrombotic events.

Conclusions:

  • Thromboprophylaxis is a consideration for children with MIS-C.
  • Patient-specific factors and biomarkers like D-dimer are crucial for treatment decisions.
  • Further research is essential to define optimal anticoagulant strategies in pediatric MIS-C.

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