Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

97
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
97
Applications of RC Circuits01:22

Applications of RC Circuits

3.2K
A relaxation oscillator is one of the applications of RC circuits. A neon lamp relaxation oscillator comprises a capacitor, a resistor, a voltage source, and a lamp. The lamp acts like an open circuit, with infinite resistance until the potential difference across the lamp reaches a specific voltage. At that voltage, the lamp acts like a short circuit with zero resistance, and the capacitor discharges through the lamp, thus producing light. Once the capacitor is fully discharged through the...
3.2K
Management of Insomnia01:19

Management of Insomnia

289
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
289
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

34.8K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
34.8K
Chronopharmacokinetics: Time-Dependent Pharmacokinetics01:20

Chronopharmacokinetics: Time-Dependent Pharmacokinetics

172
Chronopharmacokinetics studies the temporal change in drug absorption and elimination. These changes can be cyclical or non-cyclical. Cyclical changes occur over a regular interval, while non-cyclical changes occur over a longer, irregular period.
Time-dependent pharmacokinetics refers to non-cyclical changes in drug rate processes over a period of time. It can lead to nonlinear pharmacokinetics, where the relationship between drug concentration and time is not proportional. Non-cyclical...
172
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.1K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Current trends in semaglutide therapy and strategies to improve its bioavailability.

Expert opinion on drug delivery·2026
Same author

Advanced therapeutic strategies and drug delivery approaches for management of oral submucosal fibrosis: a comprehensive review.

International journal of pharmaceutics·2026
Same author

Targeting pulmonary fibrosis through Solanum xanthocarpum phytochemicals: A synergistic network pharmacology and docking investigation.

Computers in biology and medicine·2026
Same author

Microbiome modulating remedies for chronic diseases: a review of current interventions and future directions.

Inflammopharmacology·2026
Same author

Exploring acenocoumarol and silodosin in non-small cell lung cancer: Insights into EGFR-linked signaling mechanisms.

F1000Research·2025
Same author

Network pharmacology and in vitro studies demonstrate modulation of fibrotic pathways by Swertia chirayita in pulmonary fibrosis.

Scientific reports·2025

Related Experiment Video

Updated: Jul 31, 2025

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

12.1K

Controlled Release Technologies for Chronotherapy: Current Status and Future Perspectives.

Bhavana B Bhat1, Chetan H Mehta2, Akhil Suresh2

  • 1Department of Pharmaceutical Management, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India.

Current Pharmaceutical Design
|May 5, 2023
PubMed
Summary
This summary is machine-generated.

Disrupted circadian rhythms, or the body's 24-hour cycles, contribute to lifestyle diseases. Chronotherapeutics offers timed treatments, optimizing drug efficacy and minimizing toxicity for better health outcomes.

Keywords:
Biological rhythmschronobiologychronopharmacokineticschronotherapeuticscircadian rhythmscontrolled release systemssynchronization

More Related Videos

The Evoked Potential Operant Conditioning System EPOCS: A Research Tool and an Emerging Therapy for Chronic Neuromuscular Disorders
10:08

The Evoked Potential Operant Conditioning System EPOCS: A Research Tool and an Emerging Therapy for Chronic Neuromuscular Disorders

Published on: August 25, 2022

3.0K
Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
05:19

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

2.4K

Related Experiment Videos

Last Updated: Jul 31, 2025

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

12.1K
The Evoked Potential Operant Conditioning System EPOCS: A Research Tool and an Emerging Therapy for Chronic Neuromuscular Disorders
10:08

The Evoked Potential Operant Conditioning System EPOCS: A Research Tool and an Emerging Therapy for Chronic Neuromuscular Disorders

Published on: August 25, 2022

3.0K
Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
05:19

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

2.4K

Area of Science:

  • Chronobiology
  • Internal Medicine
  • Pharmacology

Background:

  • Circadian rhythms are internal biological processes synchronized with a 24-hour cycle.
  • Modern lifestyle changes and shift work disrupt these natural rhythms.
  • Disrupted circadian rhythms are linked to various diseases and impact drug effectiveness.

Purpose of the Study:

  • To explore the link between circadian rhythm disruption and disease development.
  • To highlight the potential of chronotherapeutics in managing circadian-related diseases.
  • To discuss how controlled drug release technologies can aid chronotherapeutic interventions.

Main Methods:

  • Review of scientific literature on circadian rhythms and disease.
  • Analysis of the principles of chronotherapeutics and drug metabolism.
  • Examination of controlled drug release technologies for timed medication delivery.

Main Results:

  • Disrupted circadian rhythms are a significant factor in lifestyle disease etiology.
  • Timing medication administration according to circadian phases can enhance drug efficacy and reduce toxicity.
  • Chronotherapeutic approaches show promise for managing diseases influenced by biological clock variations.

Conclusions:

  • Restoring or manipulating circadian rhythms through chronotherapeutics is a viable treatment strategy.
  • Controlled drug release systems offer a technological solution for precise chronotherapeutic delivery.
  • Understanding and leveraging circadian biology is crucial for advancing disease treatment and management.