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Related Experiment Video

Updated: Jul 31, 2025

Development of a Preclinical Inhalation Model to Test Vaporized Cannabis Distillates
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A case of panic attack developing after THC-O acetate inhalation using an e-cigarette device.

Norio Sugawara1, Norio Yasui-Furukori1, Kazutaka Shimoda1

  • 1Department of Psychiatry, Dokkyo Medical University School of Medicine, Mibu, Japan.

Neuropsychopharmacology Reports
|May 5, 2023
PubMed
Summary

Tetrahydrocannabinol acetate (THC-O) poses risks, as evidenced by a case of panic attack in an 18-year-old male after vaping. This cannabinoid product is not safe for use, especially via e-cigarettes.

Keywords:
cannabinoidse-cigarette devicepanic attacksubstance abusetetrahydrocannabinol acetate

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Area of Science:

  • Cannabinoid pharmacology
  • Adolescent and young adult health
  • Substance abuse research

Background:

  • Tetrahydrocannabinol acetate (THC-O) is a cannabinoid product with limited human studies.
  • E-cigarettes are increasingly popular among youth, raising concerns about drug delivery system misuse.
  • Understanding THC-O's effects is crucial due to its growing prevalence.

Observation:

  • A case report details an 18-year-old male experiencing a panic attack after vaping THC-O via e-cigarette.
  • The individual had no prior psychiatric history and had not used delta-9 THC or THC-O before.
  • The panic attack occurred 20 minutes post-inhalation and lasted for 2 hours.

Findings:

  • THC-O inhalation via e-cigarette triggered an acute panic attack in a young adult.
  • The patient experienced complete recovery and no recurrence of panic attacks after discontinuing THC-O.
  • This case highlights potential adverse psychological effects associated with THC-O use.

Implications:

  • THC-O should not be considered a safe substance, despite potential 'loophole drug' perceptions.
  • E-cigarette devices may facilitate and accelerate the abuse of novel cannabinoid products.
  • Further research is warranted to assess the safety and long-term effects of THC-O, particularly in vulnerable populations.