[Psoriasis in children and adolescents]

Area of Science:

• Immunology
• Dermatology
• Genetics

Context:

• Psoriasis is a multifactorial, inflammatory, immune-mediated systemic condition primarily affecting the skin.
• Onset in childhood/adolescence impacts quality of life for patients and families.
• Genetic predisposition and triggers like streptococcal infections are key factors.

Purpose:

• Provide an overview of current knowledge on psoriasis in children and adolescents.
• Summarize recommendations from the updated German guideline.
• Address both common and unusual presentations, including TNF-α inhibitor-induced paradoxical psoriasis.

Summary:

• Psoriasis is a systemic inflammatory disease with significant impact on young individuals.
• Comorbidities like obesity are prevalent and harmful in pediatric psoriasis.
• Biologic therapies offer improved treatment but face underutilization issues.

Impact:

• Highlights the need for increased utilization of advanced psoriasis treatments in pediatric care.
• Emphasizes the importance of considering comorbidities in managing pediatric psoriasis.
• Offers updated guidance for clinicians managing pediatric psoriasis, including rare forms.