Related Experiment Video
Updated: Jul 31, 2025
10:17
High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
9.7K
Drug interference with biochemical laboratory tests.
Jasmina Katanić1, Bojan Stanimirov1, Vanesa Sekeruš1
1Department of Biochemistry, Medical faculty, University of Novi Sad, Novi Sad, Serbia.
Biochemia Medica
|May 5, 2023
Summary
Drug-laboratory test interactions (DLTIs) can affect up to 43% of patients, potentially leading to misdiagnoses and incorrect treatment. Recognizing these interactions is crucial for accurate clinical decisions and patient care.
Area of Science:
- Medical Biochemistry
- Clinical Laboratory Science
Background:
- Clinical laboratory practice is integral to medical decision-making, influencing 60-70% of healthcare choices.
- Biochemical laboratory tests (BLTs) are vital for diagnosis and monitoring treatment efficacy.
- Drug-laboratory test interactions (DLTIs) affect a significant patient population, potentially compromising test accuracy.
Purpose of the Study:
- To provide a comprehensive overview of current knowledge on drug-laboratory test interactions.
- To analyze the impact of drugs on biochemical laboratory tests.
- To inform medical specialists about the significance of DLTIs.
Main Methods:
- Mini-review of existing literature on drug-laboratory test interactions.
- Analysis of the effects of various drugs on BLT results.
- Compilation of information for medical professionals.
Main Results:
- DLTIs occur in up to 43% of patients, impacting laboratory test results.
- Unrecognized DLTIs can lead to misinterpreted results, delayed or incorrect diagnoses, and inappropriate treatment.
- Failure to recognize DLTIs may result in unnecessary additional tests and increased healthcare costs.
Conclusions:
- Timely recognition of DLTIs is essential to prevent adverse clinical consequences.
- Medical professionals must be aware of potential drug interferences with laboratory tests.
- Educating healthcare providers on obtaining patient medication history, especially recent drug use, is critical for accurate BLT interpretation.
Related Concept Videos
01:20Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences
536
Inductively coupled plasma–mass spectrometry (ICP–MS) is a highly selective and sensitive technique for accurate elemental analysis. Though the analysis of ICP–MS mass spectra is comparatively straightforward, it is affected by spectroscopic and non-spectroscopic interferences. Spectroscopic interferences arise when the plasma contains ionic species with an m/z value the same as the analyte ion. Spectroscopic interference can be categorized as isobaric, polyatomic ions, and...
536
01:25Atomic Absorption Spectroscopy: Interference
872
Interference leads to systematic error in atomic absorption (AA) measurements by enhancing or diminishing the analytical signal or the background. These interferences can be grouped into three main categories: spectral interference, chemical interference, and physical interference.
Spectral interference occurs when signals from other elements or molecules overlap with the analyte signal, falsely elevating or masking the analyte's absorbance. This interference can be corrected using Zeeman,...
Spectral interference occurs when signals from other elements or molecules overlap with the analyte signal, falsely elevating or masking the analyte's absorbance. This interference can be corrected using Zeeman,...
872
01:23Factors Affecting Protein-Drug Binding: Drug Interactions
222
Drug interactions are a critical aspect of pharmacology and can occur when two or more drugs compete for the same binding site. This competition can result in one drug displacing another, altering the effect of the displaced drug. Drug interactions are complex processes that rely heavily on how much of the displacer drug is present and how strongly it can bind to the same sites as the displaced drug.
Displacement interactions can have varying outcomes, ranging from toxicity to virtually...
Displacement interactions can have varying outcomes, ranging from toxicity to virtually...
222
01:21Factors Affecting Drug Biotransformation: Physicochemical and Chemical Properties of Drugs
306
A drug's physicochemical properties fundamentally influence its metabolism. For instance, a drug's molecular size and shape critically determine its interaction with enzymes and transporters — larger drugs may face difficulty reaching enzyme active sites, altering their metabolic pathways. The pKa of a drug, which establishes its ionization state, can impact its solubility and absorption, thereby influencing metabolism.
The drug's acidity or basicity is essential in...
The drug's acidity or basicity is essential in...
306
01:23Drug Concentrations: Measurements
426
Drug concentration is the quantity of a drug present in a biological sample. Measuring drug amounts in biological samples allows the clinician to understand how a drug is absorbed, distributed, metabolized, and excreted. Samples can be obtained through invasive or non-invasive methods. Invasive techniques involve surgical or parenteral interventions to gather blood, cerebrospinal fluid, or tissue biopsy. Conversely, non-invasive approaches provide samples like urine, feces, and saliva.
Plasma...
Plasma...
426
01:29Drugs Affecting Neurotransmitter Synthesis
1.5K
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
1.5K