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Papillary renal neoplasm with reverse polarity: A case report
Chengjuan Xing1, Hui Tian2, Yunkun Zhang1
1Department of Pathology, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Frontiers in Oncology
|May 5, 2023
Summary
Papillary renal neoplasm with reverse polarity (PRNRP) is a rare kidney tumor. This case study details its unique features, KRAS mutation, and successful surgical removal with no recurrence.
Area of Science:
- Uropathology
- Oncology
- Nephrology
Background:
- Papillary renal neoplasm with reverse polarity (PRNRP) is a recently identified rare renal tumor.
- PRNRP exhibits distinct histomorphological and immunophenotypic characteristics.
- This tumor type is often associated with KRAS mutations and demonstrates indolent behavior.
Observation:
- A case of PRNRP is presented with detailed histomorphological and immunophenotypic analysis.
- Tumor cells showed positivity for GATA-3, KRT7, EMA, E-Cadherin, Ksp-Cadherin, 34βE12, and AMACR.
- Focal positivity for CD10 and Vimentin, with negativity for CD117, TFE3, RCC, and CAIX was noted.
Findings:
- KRAS mutations in exon 2 were confirmed using ARMS-PCR.
- NRAS and BRAF V600 mutations were notably absent.
- The patient underwent successful Robot-Assisted Laparoscopic Partial Nephrectomy.
Implications:
- This case contributes to the understanding of PRNRP's unique features and mutational landscape.
- The findings support the indolent nature of PRNRP, with no recurrence observed during 18 months of follow-up.
- Robot-assisted surgery offers a viable treatment option for PRNRP, preserving renal function.
