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Updated: Jul 31, 2025

An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy
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COVID-19 and Vaccination Status in Lysosomal Storage Diseases: A Single-Center Experience

Merve Yoldaş Çelik1, Ebru Canda1, Havva Yazıcı1

  • 1Division of Pediatric Metabolism and Nutrition, Department of Pediatrics, Ege University Faculty of Medicine, İzmir, Turkey.

Turkish Archives of Pediatrics
|May 5, 2023
PubMed

Insights

Lysosomal storage disease patients show no increased COVID-19 risk. Vaccination is protective against severe coronavirus disease, indicating good outcomes for this population.

Area of Science:

  • Rare diseases
  • Genetics
  • Immunology

Background:

  • Lysosomal storage diseases (LSDs) are a group of rare genetic disorders.
  • COVID-19 poses significant risks to individuals with chronic health conditions.
  • Limited data exists on COVID-19 outcomes in LSD patients.

Purpose of the Study:

  • To assess COVID-19 vaccination status in LSD patients.
  • To evaluate the impact of COVID-19 infection on individuals with LSDs.

Main Methods:

  • A cohort of 87 patients with various LSDs (Gaucher, MPS I, II, IVA, VI, VII, Fabry, Pompe) was studied.
  • Data on SARS-CoV-2 exposure, symptoms, and vaccination was collected via questionnaires.
  • In-person or phone interviews were conducted for data acquisition.

Main Results:

  • 9.1% of LSD patients tested positive for COVID-19.
  • Most COVID-19 cases in LSD patients were mild, requiring home quarantine.
  • 63.5% of LSD patients aged 12 and above were vaccinated against COVID-19.

Conclusions:

  • LSD patients do not appear to have a higher risk of severe COVID-19 compared to the general population.
  • COVID-19 vaccination offers protection against severe disease in individuals with LSDs.
Abstract

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