Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Study Designs in Epidemiology01:20

Study Designs in Epidemiology

299
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
299
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

3.5K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.5K
Bone Disorders01:29

Bone Disorders

3.7K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.7K
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

4.2K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
4.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Examining the feasibility and preliminary effects of resistance exercise training and creatine supplementation in individuals treated for colorectal cancer.

PloS one·2026
Same author

A Comparison of Fixed Percentage of One-Repetition Maximum, Rating of Perceived Exertion, and Last Repetition Velocity-Based Training Load Prescription on Muscular Adaptations in Older Adults.

Journal of strength and conditioning research·2026
Same author

Habitual creatine intake is associated with greater lean body mass and handgrip strength in the U.S. general population.

Nutrition and health·2026
Same author

Creatine Supplementation Dose and Duration Are Not Associated with Increased Side Effects: A Structured Review and Study-Level Dose-Response Analysis of Randomized Controlled Trials.

Sports (Basel, Switzerland)·2026
Same author

A Perceptually Regulated Exercise Test for Predicting Maximal Oxygen Consumption in Masters Track-and-Field Athletes.

Journal of aging and physical activity·2026
Same author

Canadian Rheumatology Association Living Guidelines for Rheumatoid Arthritis: Update #3.

The Journal of rheumatology·2026

Related Experiment Video

Updated: Jul 31, 2025

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
06:13

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health

Published on: December 1, 2023

1.2K

A 2-yr Randomized Controlled Trial on Creatine Supplementation during Exercise for Postmenopausal Bone Health.

Philip D Chilibeck1, Darren G Candow2, Julianne J Gordon1

  • 1College of Kinesiology, University of Saskatchewan, Saskatoon, SK, CANADA.

Medicine and Science in Sports and Exercise
|May 5, 2023
PubMed
Summary

Creatine monohydrate supplementation did not affect bone mineral density in postmenopausal women over two years. However, it improved bone geometry and increased lean tissue mass, suggesting potential benefits for bone strength.

More Related Videos

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

12.7K
The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
04:23

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

428

Related Experiment Videos

Last Updated: Jul 31, 2025

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
06:13

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health

Published on: December 1, 2023

1.2K
Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

12.7K
The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
04:23

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

428

Area of Science:

  • Exercise Science
  • Nutritional Biochemistry
  • Gerontology

Background:

  • Postmenopausal osteoporosis is a significant health concern, characterized by decreased bone mineral density (BMD) and increased fracture risk.
  • Creatine monohydrate is a popular supplement known for enhancing muscle performance, but its effects on bone health in women are less understood.

Purpose of the Study:

  • To investigate the long-term effects of creatine monohydrate supplementation combined with a structured exercise program on bone health in postmenopausal women.
  • To assess changes in bone mineral density (BMD) and proximal femur geometric properties.

Main Methods:

  • A 2-year randomized controlled trial involving 237 postmenopausal women.
  • Participants received either creatine monohydrate (0.14 g·kg-1·d-1) or a placebo.
  • A concurrent exercise program included resistance training (3 d·wk-1) and walking (6 d·wk-1).

Main Results:

  • Creatine supplementation showed no significant effect on femoral neck, total hip, or lumbar spine BMD compared to placebo.
  • However, creatine significantly improved section modulus and buckling ratio at the femoral neck, indicating better bone strength and resistance to fracture.
  • Creatine supplementation reduced walking time over 80 meters and increased lean tissue mass in completers, but did not enhance muscular strength.

Conclusions:

  • Two years of creatine supplementation and exercise in postmenopausal women did not alter BMD.
  • Creatine supplementation, however, positively influenced bone geometric properties, suggesting a potential role in maintaining bone structural integrity.
  • Further research is warranted to explore the mechanisms and clinical implications of these findings.