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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Intestinal barrier dysfunction: an evolutionarily conserved hallmark of aging.

Anna M Salazar1, Ricardo Aparicio2, Rebecca I Clark3

  • 1Department of Molecular Biology and Chemistry, Christopher Newport University, Newport News, VA 23606, USA.

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Summary

Maintaining intestinal barrier integrity is crucial for organismal health during aging. Targeting this barrier can promote longevity and healthy aging across species.

Keywords:
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Area of Science:

  • Gerontology
  • Gastroenterology
  • Molecular Biology

Background:

  • Intestinal barrier integrity is vital for organismal health throughout life.
  • Intestinal barrier dysfunction is a conserved feature of aging across diverse species, including worms, flies, fish, rodents, and primates.
  • Age-onset intestinal barrier dysfunction is associated with microbial shifts, immune activation, metabolic changes, systemic decline, and mortality.

Purpose of the Study:

  • To review the current understanding of age-onset intestinal barrier dysfunction.
  • To explore the relationship between intestinal barrier integrity and systemic aging.
  • To highlight the potential of targeting intestinal barrier integrity for promoting healthy aging.

Main Methods:

  • Review of existing literature on intestinal barrier function in aging organisms.
  • Analysis of studies in model organisms like Drosophila and mice.
  • Synthesis of findings linking barrier integrity to longevity and systemic health.

Main Results:

  • Intestinal barrier dysfunction is a conserved hallmark of aging.
  • This dysfunction is linked to various age-related pathologies and reduced lifespan.
  • Studies in Drosophila and mice suggest targeting intestinal barrier integrity can extend lifespan.

Conclusions:

  • Age-onset intestinal barrier dysfunction is a significant factor in overall health decline.
  • Understanding its causes and consequences is key to developing interventions for healthy aging.
  • Directly improving intestinal barrier integrity shows promise as a strategy to promote longevity.