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Risk factors associated with short- and long-term kidney injury in children with post infectious glomerulonephritis

Douglas G Matsell1, Dan Cojocaru2, Marisa Catapang2

  • 1Department of Pediatrics, Division of Nephrology, British Columbia Children's Hospital, University of British Columbia, 4480 Oak Street, Vancouver, BC, K4-156, Canada. dmatsell@cw.bc.ca.

Pediatric Nephrology (Berlin, Germany)
|May 5, 2023
PubMed

Insights

Post infectious glomerulonephritis (PIGN) in children can lead to acute kidney injury (AKI). Shorter nephrologist wait times and lower C3 levels are key risk factors for AKI and long-term kidney damage.

Area of Science:

  • Pediatric Nephrology
  • Glomerular Diseases
  • Kidney Injury

Background:

  • Post infectious glomerulonephritis (PIGN) is a leading cause of acute kidney injury (AKI) in children.
  • Understanding risk factors for kidney injury in PIGN is crucial for pediatric care.

Purpose of the Study:

  • To identify risk factors for acute kidney injury (AKI) and composite kidney injury in children with PIGN.
  • Evaluate factors associated with short- and long-term kidney damage in pediatric PIGN cases.

Main Methods:

  • Retrospective cohort study of 125 children with PIGN.
  • Assessed risk factors for AKI at presentation and composite kidney injury at follow-up using logistic regression.

Main Results:

  • 66% of patients presented with AKI.
  • Independent risk factors for AKI included shorter time to nephrologist, low nadir C3, antihypertensive use, and nephrotic proteinuria.
  • Older age and low nadir C3 were risk factors for long-term kidney injury.

Conclusions:

  • PIGN is a significant cause of pediatric AKI.
  • Initial illness severity predicts short- and long-term kidney injury.
  • Identifying high-risk cases can guide surveillance strategies.
Abstract

Keywords:
Acute kidney injuryChildhoodComplement C3OutcomesPost infectious glomerulonephritisRisk factors

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