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Mouse Models of Phaeohyphomycosis.

Yi Zhang1,2,3,4, Ruoyu Li1,2,3,4

  • 1Department of Dermatology and Venereology, Peking University First Hospital, Beijing, China.

Methods in Molecular Biology (Clifton, N.J.)
|May 5, 2023
PubMed
Summary

This study details a new mouse model for studying subcutaneous phaeohyphomycosis, a fungal infection. Card9 knockout mice showed increased susceptibility, similar to human CARD9-deficient patients, aiding in developing new treatments.

Keywords:
Dematiaceous fungiImmunityMouse modelsPhaeohyphomycosisSubcutaneous infection

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Area of Science:

  • Mycology
  • Immunology
  • Infectious Diseases

Background:

  • Phaeohyphomycosis, caused by dematiaceous fungi, is an emerging global health concern.
  • Clinical presentations of phaeohyphomycosis vary widely in humans.
  • Mouse models are crucial for understanding these fungal infections and human disease parallels.

Purpose of the Study:

  • To describe the successful construction of a mouse model for subcutaneous phaeohyphomycosis.
  • To investigate the role of CARD9 in susceptibility to dematiaceous fungal infections using this model.
  • To provide a resource for future phaeohyphomycosis research, including diagnostics and therapeutics.

Main Methods:

  • Development of a subcutaneous phaeohyphomycosis mouse model.
  • Comparison of infection phenotypes between Card9 knockout and wild-type mice.
  • Characterization of immune responses and fungal burden in the model.

Main Results:

  • The constructed mouse model effectively mimics human subcutaneous phaeohyphomycosis.
  • Card9 knockout mice exhibited significantly higher susceptibility and altered phenotypes compared to wild-type mice.
  • These findings correlate with increased susceptibility in CARD9-deficient human patients.

Conclusions:

  • The established mouse model is a valuable tool for studying phaeohyphomycosis.
  • The model highlights the critical role of CARD9 in antifungal immunity against dematiaceous fungi.
  • This research can accelerate the development of novel diagnostic and therapeutic strategies for phaeohyphomycosis.