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Infecting Mice with Malassezia spp. to Study the Fungus-Host Interaction

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Published on: November 6, 2019

Mouse Models of Mucormycosis.

Ilse D Jacobsen^1,2

¹Research Group Microbial Immunology, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute (HKI), Jena, Germany. ilse.jacobsen@leibniz-hki.de.

Methods in Molecular Biology (Clifton, N.J.)

|May 5, 2023

Summary

This study details methods for creating animal models of mucormycosis, a severe fungal infection. These models utilize specific immunosuppression techniques and infection routes to mimic human disease, aiding therapeutic development.

Keywords:

Dissemination Immunosuppression Intranasal application Intratracheal application Ketoacidosis Lichtheimia Mucor Rhizopus

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Area of Science:

Medical Mycology
Infectious Diseases
Animal Models

Background:

Mucormycosis is a rare but often fatal fungal infection.
Understanding mucormycosis pathogenesis requires relevant animal models.
Existing models vary due to diverse patient risk factors and infection routes.

Purpose of the Study:

To describe methods for inducing immunosuppression and risk factors in animal models of mucormycosis.
To detail intranasal inoculation techniques for establishing pulmonary fungal infections.
To discuss clinical parameters for scoring systems and humane endpoints in mouse models.

Main Methods:

Induction of high-dose corticosteroid or leukopenia-induced immunosuppression.
Induction of diabetic ketoacidosis as a risk factor.
Intranasal application for establishing pulmonary mucormycosis models.

Main Results:

Established protocols for creating distinct mucormycosis models in mice.
Demonstrated methods for simulating key risk factors and infection routes.
Identified clinical parameters for disease monitoring and ethical endpoint determination.

Conclusions:

Standardized animal models are essential for studying mucormycosis.
These methods facilitate research into mucormycosis pathogenesis and treatment.
The described approaches support the development of effective therapies for this devastating infection.