Proglumide fails to increase food intake after an ingested preload.

Area of Science:

• Physiology
• Pharmacology

Background:

• Cholecystokinin (CCK) is implicated in satiety.
• Proglumide antagonizes CCK.
• Previous studies suggested endogenous CCK's role in satiety.

Purpose of the Study:

• To investigate the role of endogenous cholecystokinin (CCK) in satiety.
• To determine if proglumide reliably affects food intake after oral preloads.

Main Methods:

• Rats were administered proglumide and/or oral preloads.
• Test meal intake was measured.
• Proglumide's effect on CCK-8 induced food intake reduction was confirmed.

Main Results:

• Proglumide did not increase test meal intake following oral preloads.
• Proglumide confirmed to antagonize exogenous CCK-8's satiating effect.

Conclusions:

• The satiating effect of endogenous CCK was not reliably demonstrated.
• Further research is needed to confirm endogenous CCK's role in satiety.