Related Experiment Video

Updated: May 20, 2026

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
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Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

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Wave-controlled aliasing in parallel imaging (Wave-CAIPI): Accelerating speed for the MRI-based diagnosis of

Hyunji Oh1, Younghee Yim1, Mi Sun Chung1

  • 1Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Republic of Korea.

Plos One
|May 5, 2023
PubMed
Abstract

Insights

Accelerated Wave-CAIPI MPRAGE offers reliable diagnostic performance for intracranial lesions, matching conventional MPRAGE in half the scan time. This technique enhances lesion detection and diagnosis with fewer motion artifacts.

Area of Science:

  • Radiology
  • Medical Imaging
  • Neuroimaging

Background:

  • Conventional magnetization-prepared rapid gradient-echo (MPRAGE) is a standard MRI sequence for evaluating intracranial lesions.
  • Accelerated imaging techniques are crucial for improving patient comfort and throughput in MRI.

Purpose of the Study:

  • To validate the diagnostic performance of accelerated post-contrast Wave-controlled aliasing in parallel imaging (Wave-CAIPI) MPRAGE for intracranial lesions.
  • To compare Wave-CAIPI MPRAGE with conventional MPRAGE in terms of diagnostic accuracy, image quality, and scan time.

Main Methods:

  • Retrospective evaluation of 233 patients who underwent both Wave-CAIPI MPRAGE and conventional MPRAGE.
  • Independent assessment of lesion detection, diagnosis, quantitative parameters (SNR, CNR, contrast rate), qualitative parameters, and image quality by two radiologists.
  • Statistical analysis using weighted kappa and percent agreement to assess diagnostic concordance.

Main Results:

  • Wave-CAIPI MPRAGE demonstrated high agreement with conventional MPRAGE for detecting (98.7%) and diagnosing (97.8%) enhancing intracranial lesions.
  • Comparable diagnostic performance was observed for non-enhancing lesions and lesion diameter.
  • While SNR was lower, Wave-CAIPI MPRAGE showed comparable CNR, higher contrast rate, and reduced motion artifacts, despite slightly poorer overall image quality.

Conclusions:

  • Accelerated Wave-CAIPI MPRAGE provides reliable diagnostic performance for enhancing intracranial lesions.
  • This technique significantly reduces scan time by nearly half compared to conventional MPRAGE.
  • Wave-CAIPI MPRAGE is a viable alternative for efficient and accurate neuroimaging of intracranial lesions.

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