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Published on: September 20, 2019
Equitable Access to Clinical Trials: How Do We Achieve It?
Ana Acuña-Villaorduña1, Joaquina Celebre Baranda2, Jessica Boehmer3
1Cancer Immunotherapy Program, Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY.
Abstract:
The mismatch between the study populations participating in oncology clinical trials and the composition of the targeted cancer population requires urgent amelioration. Regulatory requirements can mandate that trial sponsors enroll diverse study populations and ensure that regulatory revue prioritizes equity and inclusivity. A variety of projects directed at increasing accrual of underserved populations to oncology clinical trials emphasize best practices: broadened eligibility requirements for trials, simplification of trial procedures, community outreach through patient navigators, decentralization of clinical trial procedures and institution of telehealth, and funding to offset costs of travel and lodging. Substantial improvement will require major changes in culture in the educational and professional practice, research, and regulatory communities and will require major increases in public, corporate, and philanthropic funding.
Insights
Improving oncology clinical trial diversity is crucial. Strategies include broader eligibility, simplified procedures, community outreach, telehealth, and financial support to ensure equitable cancer research participation.
Area of Science:
- Oncology
- Clinical Trials
- Health Equity
Background:
- Significant disparities exist between oncology clinical trial participants and the general cancer patient population.
- This mismatch hinders the generalizability of trial findings and perpetuates health inequities.
Purpose of the Study:
- To highlight the urgent need for diverse patient accrual in oncology clinical trials.
- To outline current strategies and best practices aimed at increasing participation of underserved populations.
Main Methods:
- Review of current initiatives and best practices for enhancing diversity in clinical trials.
- Emphasis on regulatory mandates for equity and inclusivity.
Main Results:
- Effective strategies include broadening eligibility criteria, simplifying trial processes, and implementing community outreach programs.
- Decentralization of trial procedures, use of telehealth, and financial assistance for participants are also key.
Conclusions:
- Achieving substantial improvement in diversity requires significant cultural shifts across educational, professional, research, and regulatory sectors.
- Increased public, corporate, and philanthropic funding is essential to support these changes and ensure equitable cancer research.
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