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Updated: Jul 31, 2025

Spotting Cheetahs: Identifying Individuals by Their Footprints
Published on: May 1, 2016
Tails don't tell the whole story
1Department of Biochemistry & Cell Biology, Chobanian& Avedisian School of Medicine, Boston University, Boston, MA 02115, USA; Department of Biology, College of Arts & Sciences, Boston University, Boston, MA 02115, USA.
Abstract:
Before engaging G protein-coupled receptors (GPCRs) to transduce extracellular signals, heterotrimeric G proteins (Gαβγ) must fold properly with the help of chaperones. In this issue of Structure, Papasergi-Scott et al. (2023) unveil the molecular basis for how mammalian Ric-8 chaperones achieve selectivity for their respective Gα subunit clients.
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