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Updated: Jul 31, 2025

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

10.5K

Oncogenic signaling-mediated regulation of chromatin during tumorigenesis

Jahangir Alam1, Md Nazmul Huda1, Alan J Tackett1,2

  • 1Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Cancer Metastasis Reviews
|May 5, 2023
PubMed

Insights

Dysregulated signaling pathways, including TGF-β, Hippo, Wnt, Notch, and PI3K-AKT, alter chromatin and epigenetics, driving cancer development and spread. Understanding these epigenetic modifications is key to cancer research.

Area of Science:

  • Cellular biology
  • Molecular biology
  • Cancer research

Background:

  • Signaling pathways are crucial for cellular functions and gene expression.
  • Dysregulation of these pathways is linked to disease, especially cancer.
  • Epigenetic modifications play a significant role in cellular processes.

Purpose of the Study:

  • To review how specific signaling pathways modulate chromatin modifications.
  • To explore the role of epigenome regulation in tumorigenesis and metastasis.
  • To highlight the connection between signaling pathway dysregulation and cancer development.

Main Methods:

  • Literature review of signaling pathways and epigenetics.
  • Analysis of the interplay between signaling pathways and chromatin modifications.
  • Discussion of key pathways: TGF-β, Hippo, Wnt, Notch, and PI3K-AKT.

Main Results:

  • Signaling pathway dysregulation alters chromatin modifications.
  • These epigenetic changes contribute to the regulation of the epigenome.
  • The discussed pathways are implicated in promoting tumorigenesis and metastasis.

Conclusions:

  • Epigenetic alterations driven by signaling pathway dysregulation are central to cancer.
  • Targeting these pathways and their epigenetic effects may offer therapeutic strategies.
  • Further research into signaling pathway-epigenome interactions is vital for cancer treatment.
Keywords:
Carcinogenesis and metastasisEpigeneticsSignaling

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