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[Thyroid Eye Disease-Compressive Optic Neuropathy].

Aylin Garip Kuebler1, Kathrin Halfter2, Annemarie Klingenstein3

  • 1Department of Ophthalmology, Ludwig-Maximilians-University, Mathildenstr. 8, 80336, Munich, Deutschland. Aylin.Garip-Kuebler@med.uni-muenchen.de.

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This summary is machine-generated.

Thyroid eye disease-compressive optic neuropathy (TED-CON) treatment improves visual acuity in most patients. However, visual field defects often persist, indicating lasting optic nerve compression effects.

Keywords:
ExophthalmosGraves’ diseaseOrbitVisual field

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Area of Science:

  • Ophthalmology
  • Endocrinology
  • Neurology

Background:

  • Optic nerve compression in thyroid eye disease (TED-CON) can lead to significant visual impairment.
  • Evaluating functional outcomes is crucial for managing TED-CON patients.

Purpose of the Study:

  • To assess the functional outcomes, specifically best-corrected visual acuity (BCVA) and visual field (VF) defects, in patients with TED-CON post-treatment.
  • To determine the effectiveness of different treatment modalities for TED-CON.

Main Methods:

  • Observational, retrospective study including 51 patients (96 eyes) diagnosed with TED-CON between 2010-2020.
  • Analysis of medical charts to evaluate BCVA and VF outcomes after treatments such as steroid-pulse therapy and surgical orbital decompression.

Main Results:

  • Improvement in BCVA (≥2 lines) was observed in 77.1% of eyes post-treatment, with no significant difference between treatment methods.
  • Complete resolution of VF defects occurred in 27.2% of eyes, while 61.1% had residual VF defects after a minimum 6-month follow-up.
  • A good final BCVA (≥0.8) was achieved in over half of the TED-CON cases.

Conclusions:

  • While BCVA generally recovers well in TED-CON patients, visual field defects frequently persist.
  • Residual VF defects suggest that optic nerve compression can have long-term impacts despite treatment.
  • Further research may be needed to optimize VF recovery in TED-CON.