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Updated: Jul 31, 2025

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
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Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

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The psoriasis area and severity index is an independent risk factor for cardiovascular events: A prospective register

A Svedbom1,2, M Ståhle1,2

  • 1Department of Medicine, Division of Dermatology and Venereology, Karolinska Institutet, Stockholm, Sweden.

Journal of the European Academy of Dermatology and Venereology : JEADV
|May 6, 2023
PubMed

Insights

Psoriasis disease activity, measured by the Psoriasis Area and Severity Index (PASI), independently predicts future cardiovascular events in patients with moderate-to-severe psoriasis. Higher PASI scores indicate increased cardiovascular risk.

Area of Science:

  • Dermatology
  • Cardiology
  • Public Health

Background:

  • Systemic psoriasis treatments are linked to higher cardiovascular disease (CVD) risk.
  • Limited data exist on the association between psoriasis disease activity and future cardiovascular events.

Purpose of the Study:

  • To assess the relationship between the Psoriasis Area and Severity Index (PASI) and cardiovascular events.
  • To determine if PASI can identify patients at increased CVD risk.

Main Methods:

  • Linked prospective data on PASI and CVD risk factors with administrative hospitalization and death records.
  • Utilized Cox proportional hazard models with time-varying covariates for PASI and Framingham 10-year cardiovascular risk.

Main Results:

  • A total of 767 patients and 6264 PASI scores were analyzed.
  • Each one-point increase in PASI was associated with a 4% increased hazard of cardiovascular events (HR 1.04, 95% CI: 1.01-1.07), after adjusting for CVD risk factors.
  • Findings remained significant in sensitivity analyses.

Conclusions:

  • The Psoriasis Area and Severity Index (PASI) serves as an independent predictor of future cardiovascular events.
  • Clinical disease activity in psoriasis is a modifiable risk factor for cardiovascular events.
Abstract

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