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Bone morphogenetic proteins in spine surgery: a scientometric analysis to date.

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This study analyzed the most cited bone morphogenetic protein (BMP) literature, revealing a shift from basic science to clinical applications, particularly in spine surgery. Further clinical trials are recommended to compare BMP efficacy against other treatments.

Keywords:
bone morphogenetic proteinfusiongrowth differentiation factorspinal surgeryspine

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Area of Science:

  • Biomedical Engineering
  • Orthopedics
  • Regenerative Medicine

Background:

  • Bone morphogenetic proteins (BMPs) are crucial for bone formation and repair, belonging to the transforming growth factor-beta superfamily.
  • Recombinant human BMP (rhBMP) is utilized in spine surgery as an alternative to autografts for spinal fusions.

Purpose of the Study:

  • To conduct a bibliometric analysis of the scientific literature on BMPs.
  • To provide an overview of the evolution of BMP research and its applications.

Main Methods:

  • A comprehensive literature search was performed using Scopus database from 1955 to the present.
  • Bibliometric parameters of the 100 most cited articles were extracted and analyzed using R 4.1.1.

Main Results:

  • The 100 most cited articles (1994-2018) had an average of 279 citations per publication.
  • The United States led in citations, with Emory University, Hughston Clinic, and Hospital for Special Surgery as leading institutions.
  • Most publications focused on clinical applications, especially in spine surgery.

Conclusions:

  • BMP research has transitioned from basic science to clinical applications, with a significant focus on spine surgery.
  • Future research should prioritize controlled clinical trials comparing BMPs with alternative treatments for spine fusion.