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SEOM-GEICAM-SOLTI clinical guidelines in advanced breast cancer (2022)

Jose Angel Garcia-Saenz1, Isabel Blancas2, Isabel Echavarria3

  • 1Medical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), CIBERONC, Madrid, Spain. jgsaenz@salud.madrid.org.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|May 6, 2023
PubMed

Insights

Managing advanced breast cancer requires understanding its genomic changes and treatment resistance. These guidelines offer evidence-based therapies to improve patient quality of life and survival.

Area of Science:

  • Oncology
  • Genomics
  • Medical Therapeutics

Background:

  • Advanced breast cancer presents significant challenges due to genomic alterations leading to treatment resistance.
  • Improving patient quality of life and survival is a primary objective in managing this complex disease.

Purpose of the Study:

  • To summarize current evidence and available therapies for advanced breast cancer.
  • To guide medical management based on the disease's natural history.

Main Methods:

  • Review of current scientific literature.
  • Synthesis of evidence on therapeutic options.
  • Analysis of treatment resistance mechanisms.

Main Results:

  • Identification of key genomic changes driving treatment resistance.
  • Overview of established and emerging therapies.
  • Guidance on selecting subsequent treatments.

Conclusions:

  • Understanding the dynamic genomic landscape is crucial for effective advanced breast cancer management.
  • Personalized therapeutic strategies based on disease progression can enhance patient outcomes.
Keywords:
ABCADCAdvanced breast cancerAnti-HER2 therapyEndocrine therapyGuidelinesIOT

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