Satiety for glucose solution in rat: the specificity is postingestive

Rats that have drunk a concentrated glucose solution to satiety, and will drink no more of it if access is prolonged, will return to vigorous ingestion if offered carbohydrate powder or laboratory chow. We show that this specificity of satiety is maintained even if the initial glucose load is delivered directly to the stomach, bypassing the stimuli and the responses associated with spontaneous ingestion. Therefore, the specificity of satiety for glucose does not reflect sensory- or response-specific satiety.