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Causal relationship between Gut Microbiota and Obstructive sleep apnea.

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  • 1Department of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.

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|May 6, 2023
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Summary

Mendelian randomization revealed specific gut bacteria causally linked to obstructive sleep apnea (OSA). Certain bacteria like Peptostreptococcaceae may increase OSA risk, while others like Acidaminococcaceae may reduce it.

Keywords:
Causal associationGenome-wide association studyGut microbiotaMendelian RandomizationObstructive sleep apnea

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Area of Science:

  • Microbiome research
  • Genetics
  • Sleep medicine

Background:

  • Observational studies suggest a link between gut microbiota and obstructive sleep apnea (OSA).
  • Causal relationships between gut microbiota and OSA remain unclear.
  • Mendelian randomization (MR) is a robust method for investigating causality.

Purpose of the Study:

  • To investigate the causal relationship between gut microbiota and obstructive sleep apnea (OSA).
  • To identify specific gut bacteria that may influence OSA risk.
  • To explore potential mechanisms of gut microbiota-mediated OSA development.

Main Methods:

  • Utilized summary-level genome-wide association study (GWAS) data for gut microbiota (MiBioGen consortium) and OSA (FinnGen Consortium).
  • Employed a two-sample Mendelian randomization (MR) approach with inverse variance-weighted (IVW) as the primary analysis.
  • Assessed results for pleiotropy and heterogeneity; conducted reverse MR analysis.

Main Results:

  • Identified four gut microbiota with nominally significant associations to OSA.
  • Family Peptostreptococcaceae and genus Coprococcus3 showed a potential increased risk of OSA.
  • Family Acidaminococcaceae and genus Blautia indicated a potential ameliorative effect on OSA.
  • No significant pleiotropy or heterogeneity was detected.

Conclusions:

  • MR analysis supports a causal link between specific gut microbiota and OSA at the genetic level.
  • Findings provide novel insights into the mechanisms underlying gut microbiota's role in OSA.
  • Highlights potential targets for future interventions in OSA management.