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An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
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Stress, inflammation, microbiome and depression

Eva M Medina-Rodriguez1, Alyssa A Cruz2, Julia Cavati De Abreu2

  • 1Department of Psychiatry and Behavioral Sciences, United States of America; Bruce W. Carter Department of Veterans Affairs Medical Center, Miami, FL 33125, United States of America.

Pharmacology, Biochemistry, and Behavior
|May 6, 2023
PubMed

Insights

Major depressive disorder (MDD) is linked to gut microbiome and inflammation changes, influenced by stress. Understanding the brain-gut axis offers new avenues for treating this prevalent psychiatric disorder.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Microbiology

Background:

  • Psychiatric disorders, including major depressive disorder (MDD), are increasingly prevalent globally.
  • MDD is a debilitating condition with limited effective treatment options.
  • Emerging evidence implicates microbial and immunological alterations in depression's development.

Conclusions:

  • The gut microbiome and inflammation are critical factors in major depressive disorder.
  • Stress exacerbates these changes, highlighting the importance of the brain-gut axis.
  • Targeting the gut microbiome and inflammatory pathways may offer novel therapeutic strategies for MDD.
Keywords:
DepressionInflammationMicrobiomeStress

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