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Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

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Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
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An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
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Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
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Genome-wide Association Studies-GWAS01:11

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Once the aorta traverses the diaphragmatic plane at the aortic hiatus, it is known as the abdominal aorta. This anatomical structure is positioned leftward of the spinal column, encased within a cocoon of adipose tissue behind the peritoneal cavity. It terminates at the L4 vertebra, where it splits into the common iliac arteries. Prior to this bifurcation, the abdominal aorta gives rise to several vital branches.
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Peripheral Artery Disease I: Introduction01:30

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs but also impacts other areas, such as the arms, thereby impairing overall circulation and organ function.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty deposits inside the arterial...
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Association between gout and abdominal aortic aneurysm.

Jen-Chun Wang1, Shih-Hung Tsai2, Wu-Chien Chien3

  • 1Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Journal of Cardiology
|May 6, 2023
PubMed
Summary

Gout significantly increases the risk of developing abdominal aortic aneurysm (AAA). However, treatment with anti-gout medications may lower this risk, suggesting a link between gout and AAA development.

Keywords:
Abdominal aortic aneurysmHyperuricemiaUric acid

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Area of Science:

  • Cardiovascular Research
  • Rheumatology
  • Epidemiology

Background:

  • Hyperuricemia is linked to microvascular issues, but its relation to abdominal aortic aneurysm (AAA) is not well-defined.
  • Gout, a condition characterized by high uric acid levels, has an unclear association with AAA formation.

Purpose of the Study:

  • To investigate the relationship between gout and the incidence of abdominal aortic aneurysm (AAA).
  • To determine if gout is an independent risk factor for AAA development.

Main Methods:

  • A population-based cohort study utilizing Taiwan's National Health Insurance Research Database.
  • Included 121,236 patients with gout and 121,236 propensity score-matched controls.
  • Followed participants for 14 years to assess cumulative AAA incidence.

Main Results:

  • Patients with gout showed a significantly higher incidence of AAA development (adjusted HR = 2.465, p < 0.001).
  • Treatment with anti-gout medications was associated with a significantly lower risk of AAA diagnosis (adjusted HR = 0.489, p < 0.001).

Conclusions:

  • This study provides clinical evidence supporting an association between gout and the development of abdominal aortic aneurysm (AAA).
  • Gout may be a risk factor for AAA, and anti-gout medication may have a protective effect.