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Updated: Jul 31, 2025
11:14
Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
Published on: October 12, 2018
9.2K
Human Immunodeficiency Virus in Pregnancy
Annie M Dude1, Maura Jones1, Tenisha Wilson1
1Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Summary
Antiretroviral therapy significantly reduces the risk of mother-to-child HIV transmission. Pregnant individuals with HIV should receive treatment to protect both their health and their baby's.
Area of Science:
- Public Health
- Infectious Diseases
- Maternal Health
Background:
- Approximately 5000 individuals with human immunodeficiency virus (HIV) give birth annually.
- Without intervention, perinatal HIV transmission rates range from 15% to 45%.
Purpose of the Study:
- To highlight the effectiveness of antiretroviral therapy (ART) in preventing perinatal HIV transmission.
- To emphasize the importance of early HIV diagnosis and treatment for pregnant individuals.
Main Methods:
- Review of existing data on perinatal HIV transmission rates.
- Analysis of the impact of antiretroviral therapy and intrapartum/postpartum interventions.
Main Results:
- Antiretroviral therapy, combined with appropriate intrapartum and postpartum care, can decrease HIV transmission rates to below 1%.
- ART also mitigates health risks for pregnant individuals living with HIV.
Conclusions:
- Universal screening and access to treatment for HIV in pregnant individuals are crucial.
- Effective management of HIV during pregnancy safeguards maternal and infant health.
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