Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

4.3K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.3K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

4.0K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.0K
Abnormal Proliferation02:23

Abnormal Proliferation

4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

1.7K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
1.7K
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

1.3K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
1.3K
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

1.7K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nonoperative Management of Locally Advanced Resectable Cutaneous Squamous Cell Cancer of the Head and Neck with PD-1 Blockade.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

JAK2 Fusions in Adult Patients With Mycosis Fungoides and CD30 Lymphoproliferative Disorders.

JAMA dermatology·2025
Same author

Thinking beyond immunotherapy: implementing a multimodal care plan to facilitate extended survival in stage IV melanoma.

Melanoma research·2025
Same author

Translational Potential of Fluorescent PARP1 Inhibitor as a Molecular Contrast Agent for Diagnosis of Basal Cell Carcinoma.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2025
Same author

Malignant CRTC1::TRIM11 Cutaneous Tumor With Lethal Outcome: Histopathologic and Molecular Findings.

Journal of cutaneous pathology·2025
Same author

Oral and Topical Janus Kinase Inhibitors in Patients With Cutaneous T-Cell Lymphoma: A Real-World Single-Center Experience.

The Journal of dermatology·2025

Related Experiment Video

Updated: Jul 31, 2025

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

5.6K

Aggressive Cutaneous Lymphomas and Their Mimics.

Andrea P Moy1, Melissa P Pulitzer1

  • 1Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

Surgical Pathology Clinics
|May 6, 2023
PubMed
Summary
This summary is machine-generated.

This review covers aggressive cutaneous lymphomas, detailing their clinical and histopathologic features. It aids in distinguishing these cancers from indolent forms and mimics for better diagnosis.

Keywords:
Adult T-cell leukemia/lymphomaCutaneous B-cell lymphomaCutaneous T-cell lymphomaCutaneous lymphomaDiffuse large B-cell lymphoma, leg typeExtranodal NK/T-cell lymphomaPrimary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphomaPrimary cutaneous gamma-delta T-cell lymphoma

More Related Videos

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.2K
Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
07:52

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma

Published on: January 9, 2019

19.8K

Related Experiment Videos

Last Updated: Jul 31, 2025

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

5.6K
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.2K
Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
07:52

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma

Published on: January 9, 2019

19.8K

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Cutaneous lymphomas are diverse neoplasms with varied presentations and prognoses.
  • Distinguishing between indolent and aggressive forms, and skin-involved systemic lymphomas, is challenging due to overlapping features.
  • Accurate diagnosis relies on integrating clinical and histopathologic findings.

Purpose of the Study:

  • To review the clinical and histopathologic characteristics of aggressive cutaneous B-cell and T-cell lymphomas.
  • To discuss indolent cutaneous lymphomas, systemic lymphomas involving the skin, and mimickers.
  • To enhance awareness of rare cutaneous lymphoma entities and recent advancements.

Main Methods:

  • Review of clinical and histopathologic features of aggressive cutaneous lymphomas.
  • Discussion of indolent cutaneous lymphomas and related conditions.
  • Synthesis of current literature and emerging developments.

Main Results:

  • Detailed description of distinctive clinical and histopathologic features of aggressive cutaneous B- and T-cell lymphomas.
  • Comparison with indolent lymphomas, systemic lymphomas, and reactive processes.
  • Identification of key diagnostic challenges and new insights.

Conclusions:

  • Clinicopathologic correlation is crucial for accurate diagnosis of cutaneous lymphomas.
  • Understanding the spectrum of cutaneous lymphomas, including rare entities, improves patient management.
  • This review provides a comprehensive overview of aggressive cutaneous lymphomas and related conditions.