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Related Concept Videos

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Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

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The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
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Related Experiment Video

Updated: Jul 31, 2025

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
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Epstein‒Barr virus-associated cellular immunotherapy.

Yi Zhang1, Hairong Lyu2, Ruiting Guo1

  • 1First Center Clinic College of Tianjin Medical University, Tianjin, China.

Cytotherapy
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PubMed
Summary
This summary is machine-generated.

Epstein-Barr virus (EBV) infects most people lifelong. EBV-specific cytotoxic T lymphocytes show promise for preventing and treating EBV-associated cancers and diseases.

Keywords:
Epstein‒Barr viruscellular Immunotherapycytotoxic T Lymphocytetherapeutic method

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An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
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Area of Science:

  • Virology
  • Immunology
  • Oncology

Background:

  • Epstein-Barr virus (EBV) is a common human herpesvirus, saliva-transmissible and causing lifelong latent infections in over 90% of the population.
  • EBV infection is linked to several cancers, including nasopharyngeal carcinoma, diffuse large B-cell lymphoma, and Burkitt lymphoma.

Purpose of the Study:

  • This review focuses on EBV-specific cytotoxic T lymphocytes (CTLs) as a therapeutic strategy.
  • It also briefly discusses therapeutic EBV vaccines and chimeric antigen receptor T-cell (CAR-T) therapy for EBV-related conditions.

Main Methods:

  • The review synthesizes findings from clinical studies on EBV-specific CTLs.
  • It examines the safety and efficacy of these cell-based therapies.

Main Results:

  • Clinical studies demonstrate that EBV-specific CTLs can be safely and effectively transfused.
  • These therapies show potential in preventing and treating EBV-driven diseases and cancers.

Conclusions:

  • EBV-specific CTLs represent a viable therapeutic approach for managing EBV-associated pathologies.
  • Further research into EBV vaccines and CAR-T therapy may offer additional treatment avenues.