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Related Experiment Videos

Craniofacial mucormycosis: assessment with CT.

J L Gamba, W W Woodruff, W T Djang

    Radiology
    |July 1, 1986
    PubMed
    Summary

    Computed tomographic (CT) scans reveal early signs of rhinocerebral mucormycosis in the sinuses. Invasive disease can extend intracranially, appearing as abscesses or infarcts, even without bone destruction.

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    Area of Science:

    • Radiology
    • Infectious Diseases
    • Neurology

    Background:

    • Rhinocerebral mucormycosis is a severe fungal infection.
    • Early diagnosis is crucial for effective treatment.
    • Computed tomographic (CT) imaging plays a key role in diagnosis.

    Purpose of the Study:

    • To evaluate the utility of CT scans in diagnosing rhinocerebral mucormycosis.
    • To describe the CT findings associated with the disease.
    • To assess CT's role in monitoring treatment response.

    Main Methods:

    • Retrospective review of CT scans from ten patients with rhinocerebral mucormycosis.
    • Analysis of paranasal sinus and intracranial involvement patterns.
    • Correlation of CT findings with clinical presentation and treatment outcomes.

    Main Results:

    • Early CT findings included mucosal thickening in paranasal sinuses, often without air/fluid levels.
    • Bone destruction was an infrequent and late finding.
    • Intracranial involvement occurred in five cases, presenting as fungal abscesses or infarcts.
    • CT demonstrated low-density masses with variable enhancement in intracerebral abscesses.
    • Serial CT scans aided in assessing treatment response.

    Conclusions:

    • CT is valuable for detecting early sinus mucosal changes in rhinocerebral mucormycosis.
    • Intracranial extension can occur without apparent bone destruction.
    • CT findings, including spared cortex, help differentiate fungal abscess from infarct.
    • Serial CT monitoring is effective for evaluating treatment efficacy.

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