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Multiple Protein Biomarkers and Different Treatment Strategies for Colorectal Carcinoma: A Comprehensive Prospective
Biswadip Chakraborty1, Shivangi Agarwal1, Shivam Kori1
1Integrated Drug Discovery Research Laboratory, Department of Pharmaceutical Sciences, Dr. Harisingh Gour University (A Central University), Sagar (MP), India.
Abstract:
In this review, we emphasized important biomarkers, pathogenesis, and newly developed therapeutic approaches in the treatment of colorectal cancer (CRC). This includes a complete description of small-molecule inhibitors, phytopharmaceuticals with antiproliferative potential, monoclonal antibodies for targeted therapy, vaccinations as immunotherapeutic agents, and many innovative strategies to intervene in the interaction of oncogenic proteins. Many factors combine to determine the clinical behavior of colorectal cancer and it is still difficult to comprehend the molecular causes of a person's vulnerability to CRC. It is also challenging to identify the causes of the tumor's onset, progression, and responsiveness or resistance to antitumor treatment. Current recommendations for targeted medications are being updated by guidelines throughout the world in light of the growing number of high-quality clinical studies. So, being concerned about the aforementioned aspects, we have tried to present a summarized pathogenic view, including a brief description of biomarkers and an update of compounds with their underlying mechanisms that are currently under various stages of clinical testing. This will help to identify gaps or shortfalls that can be addressed in upcoming colorectal cancer research.
Insights
This review covers colorectal cancer (CRC) biomarkers, pathogenesis, and novel therapies like targeted drugs and immunotherapy. Understanding CRC
Area of Science:
- Oncology
- Molecular Biology
- Pharmacology
Background:
- Colorectal cancer (CRC) presents complex challenges in understanding its pathogenesis and molecular vulnerabilities.
- Identifying the origins of CRC onset, progression, and treatment resistance remains difficult.
- Growing clinical evidence necessitates updated guidelines for targeted CRC therapies.
Purpose of the Study:
- To review key biomarkers, pathogenesis, and emerging therapeutic strategies for colorectal cancer.
- To summarize novel compounds and their mechanisms currently in clinical trials.
- To identify research gaps in colorectal cancer treatment and management.
Main Methods:
- Comprehensive literature review of colorectal cancer research.
- Analysis of small-molecule inhibitors, phytopharmaceuticals, monoclonal antibodies, and immunotherapies.
- Examination of innovative strategies targeting oncogenic protein interactions.
Main Results:
- Detailed overview of CRC biomarkers and pathogenic pathways.
- Description of diverse therapeutic agents, including targeted therapies and immunotherapies.
- Update on compounds in various stages of clinical investigation for CRC treatment.
Conclusions:
- Current understanding of CRC pathogenesis and individual susceptibility is incomplete.
- Emerging therapies offer promising avenues for colorectal cancer treatment.
- Further research is needed to address existing gaps in CRC management and drug development.
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