A Case-Control Study of Serum and Tissue Catalase among Morphological Variants of Vitiligo
Nandhini Periasamy1, V Ramesh2, Monika Matlani3
1Department of Dermatology and STD, Vardhman Mahavir Medical College and Safdarjung Hospital, Faridabad, New Delhi, India.
Background:
Role of oxidative stress in the pathogenesis of vitiligo.
Aim:
Estimation of serum and tissue catalase levels in morphological variants of vitiligo.
Settings And Design:
A prospective case-control study was conducted in the outpatient department of Dermatology in Safdarjung hospital.
Materials And Methods:
We estimated levels of serum and tissue catalase in 30 vitiligo patients and 30 matched healthy controls.
Statistical Analysis:
The data analysis was done in Statistical Package for Social Sciences (SPSS) version 21.0. Normality of data was tested by Kolmogorov-Smirnov test.
Results:
Serum and tissue catalase was lower in vitiligo patients than controls. Serum catalase was lowest in vulgaris type, whereas in the acrofacial type had lowest tissue catalase levels.
Conclusion:
Vitiligo patients have a generalized oxidative stress functioning at a higher pace as seen with decreased serum and tissue CAT which can well be taken as a marker of active disease and they can be helped with topical pseudoCAT preparations.
