The effect of chronic ethanol ingestion on the inotropic effect of nifedipine
Research Communications in Chemical Pathology and Pharmacology
|May 1, 1986
Abstract:
The effect of chronic ethanol ingestion on the positive and negative inotropic effects of nifedipine were tested using isolated rat left atria in a force transducing system. There was a significant relative and absolute decrease in the positive inotropic effect of nifedipine in tissues from rats ingesting ethanol (E) as compared to tissue from non-ethanol ingesting rats (N) at low nifedipine concentrations. This change may be mediated by a change in efficiency of the contractile apparatus or membrane fluidity.
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