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Related Experiment Video

Updated: Jul 31, 2025

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry
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CCL13 and human diseases.

Laifu Li1,2, Fei Dai1,2, Lianli Wang1,2

  • 1Department of Gastroenterology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Frontiers in Immunology
|May 8, 2023
PubMed
Summary
This summary is machine-generated.

Chemokine CCL13 (monocyte chemoattractant protein-4) plays varied roles in human diseases. This review details its involvement in conditions from cancer to rheumatic diseases, and even potential protective effects.

Keywords:
CCL13MCP-4NF-κBTh2cytokineshuman diseasestype 2 immunity

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Area of Science:

  • Immunology and Inflammation
  • Molecular Biology
  • Human Pathology

Background:

  • CCL13, also known as monocyte chemoattractant protein-4 (MCP-4), is a CC chemokine.
  • It is known to induce chemotaxis in various immune cells, indicating a role in immune responses.
  • Existing research highlights CCL13's involvement in numerous disorders, but a comprehensive analysis is lacking.

Purpose of the Study:

  • To provide a thorough analysis of CCL13's function in human disorders.
  • To outline existing CCL13-focused therapies.
  • To consolidate current understanding of CCL13's diverse roles in disease pathogenesis and potential therapeutic strategies.

Main Methods:

  • Literature review and synthesis of existing research on CCL13.
  • Comparative analysis of CCL13's role across different disease categories.
  • Examination of studies reporting CCL13's involvement, or lack thereof, in specific human conditions.

Main Results:

  • CCL13's function is well-established in rheumatic diseases, skin conditions, and cancer.
  • Evidence suggests CCL13 involvement in ocular disorders, orthopedic conditions, nasal polyps, and obesity.
  • Limited evidence links CCL13 to HIV, nephritis, and multiple sclerosis; it may have protective roles in primary biliary cholangitis and suicide.

Conclusions:

  • CCL13 exhibits diverse and context-dependent roles in human diseases, ranging from pro-inflammatory to potentially protective.
  • Understanding these varied functions is crucial for developing targeted CCL13-based therapies.
  • Further research is warranted to fully elucidate CCL13's mechanisms and therapeutic potential across the spectrum of human health and disease.