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04:33
Methods for Detecting Cough and Airway Inflammation in Mice
Published on: August 2, 2024
697
Bacterial Etiology in Subacute Cough.
Ji-Yong Moon1, Hyun Lee1, Min-Hye Kim2
1Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
Allergy, Asthma & Immunology Research
|May 8, 2023
Summary
Bacterial infections are detected in nearly 29% of subacute cough cases. Multiplex bacterial polymerase chain reaction (PCR) identified common pathogens like Haemophilus influenzae and Streptococcus pneumoniae, with Bordetella pertussis found in 5% of positive results.
Area of Science:
- Infectious Diseases
- Respiratory Medicine
- Microbiology
Background:
- Postinfectious etiology is the primary cause of subacute cough.
- Epidemiological data on bacterial infections associated with subacute cough are limited.
Purpose of the Study:
- To determine the etiology of bacterial detection in patients experiencing subacute cough.
- To investigate the prevalence of specific bacterial pathogens in subacute cough cases.
Main Methods:
- A multicenter prospective observational study involving 142 patients with postinfectious subacute cough.
- Collection of two nasal swabs per patient for multiplex bacterial polymerase chain reaction (PCR) analysis.
- Simultaneous detection of Bordetella pertussis, Chlamydophila pneumoniae, Haemophilus influenzae, Legionella pneumophilia, Mycoplasma pneumoniae, and Streptococcus pneumoniae.
Main Results:
- Bacterial PCR detected pathogens in approximately 29% (41/142) of patients.
- The most frequently identified bacteria were Haemophilus influenzae (13.4%) and Streptococcus pneumoniae (12.7%).
- Bordetella pertussis was detected in 4.9% of patients, with dual bacterial positivity observed in nine cases.
Conclusions:
- Bacterial PCR of nasal swabs identified pathogens in nearly 29% of subacute cough patients.
- Haemophilus influenzae and Streptococcus pneumoniae were the most common bacterial findings.
- The study highlights the significant role of bacterial infections, including Bordetella pertussis, in subacute cough etiology.
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