Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Flail Chest-II

Flail Chest-II

Managing flail chest, a condition characterized by a segment of the chest wall moving independently from the rest of the thoracic cage, requires a comprehensive approach. It includes a thorough assessment of the patient's condition, a diagnostic evaluation to determine the extent of the injury, and the implementation of appropriate medical interventions tailored to the individual's needs.
Assessment:
1. Clinical Evaluation:
History:

Cardiopulmonary Resuscitation II: ACLS Airway Management

Cardiopulmonary Resuscitation II: ACLS Airway Management

Airway management is a key skill in emergency and critical care settings, as maintaining a clear airway is essential for adequate oxygenation and ventilation.Head Tilt-Chin Lift TechniqueThe head tilt-chin lift maneuver is an essential technique primarily used in patients without suspected cervical spine injuries. To perform this maneuver, one hand is placed on the patient’s forehead, and gentle pressure is applied backward to tilt the head. The fingertips of the other hand are positioned...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Microglia depletion improves hippocampal circuit function after mild traumatic brain injury in male mice.

Brain, behavior, and immunity·2025

Same author

Neonatal microglia replacement in mice modulates seizure severity in adulthood.

Molecular therapy : the journal of the American Society of Gene Therapy·2025

Same author

Fool's gold standard? Immunoperoxidase staining with the mouse monoclonal antibody (Clone 22C11) for detecting axonal pathology after traumatic brain injury.

Frontiers in neuroscience·2025

Same author

Mild Traumatic Brain Injury Impairs Fear Extinction and Network Excitability in the Infralimbic Cortex.

Journal of neurotrauma·2025

Same author

Effects of Traumatic Brain Injury on the Orexin/Hypocretin System.

Neurotrauma reports·2025

Same author

Head Injury Treatment With Healthy and Advanced Dietary Supplements: A Pilot Randomized Controlled Trial of the Tolerability, Safety, and Efficacy of Branched Chain Amino Acids in the Treatment of Concussion in Adolescents and Young Adults.

Journal of neurotrauma·2024

Search research articles

Related Experiment Video

Updated: Jul 31, 2025

Maintenance of a Lateral Fluid Percussion Injury Device

Maintenance of a Lateral Fluid Percussion Injury Device

Published on: April 21, 2023

Maintenance of a Lateral Fluid Percussion Injury Device.

Anthony M Farrugia¹, Samuelle A S Delcy², Brian N Johnson³

¹Department of Anesthesiology, Perelman School of Medicine at the University of Pennsylvania.

Journal of Visualized Experiments : Jove

|May 8, 2023

Summary

Proper maintenance of the Lateral Fluid Percussion Injury (LFPI) device is crucial for reliable experimental traumatic brain injury (TBI) modeling. This guide details essential cleaning, filling, and assembly procedures for optimal results.

More Related Videos

Lateral Fluid Percussion: Model of Traumatic Brain Injury in Mice

Lateral Fluid Percussion: Model of Traumatic Brain Injury in Mice

Published on: August 22, 2011

Use of a Wireless Video-EEG System to Monitor Epileptiform Discharges Following Lateral Fluid-Percussion Induced Traumatic Brain Injury

Use of a Wireless Video-EEG System to Monitor Epileptiform Discharges Following Lateral Fluid-Percussion Induced Traumatic Brain Injury

Published on: June 21, 2019

Related Experiment Videos

Last Updated: Jul 31, 2025

Maintenance of a Lateral Fluid Percussion Injury Device

Maintenance of a Lateral Fluid Percussion Injury Device

Published on: April 21, 2023

Lateral Fluid Percussion: Model of Traumatic Brain Injury in Mice

Lateral Fluid Percussion: Model of Traumatic Brain Injury in Mice

Published on: August 22, 2011

Use of a Wireless Video-EEG System to Monitor Epileptiform Discharges Following Lateral Fluid-Percussion Induced Traumatic Brain Injury

Use of a Wireless Video-EEG System to Monitor Epileptiform Discharges Following Lateral Fluid-Percussion Induced Traumatic Brain Injury

Published on: June 21, 2019

Area of Science:

Neuroscience
Biomedical Engineering
Trauma Research

Background:

Traumatic brain injury (TBI) is a significant cause of death and disability, necessitating reliable experimental models.
Lateral Fluid Percussion Injury (LFPI) is a widely used model that mimics human TBI pathology, including hemorrhages and neuron loss.

Purpose of the Study:

To provide a detailed protocol for the proper maintenance of the LFPI device.
To ensure consistent and reliable experimental TBI induction using the LFPI model.

Main Methods:

The LFPI device utilizes a pendulum-driven piston to generate a pressure pulse transmitted to the animal's dura mater.
Animal preparation involves a craniectomy and attachment of a Luer hub for device connection.
The protocol covers essential steps for cleaning, filling, and assembling the LFPI device.

Main Results:

Consistent maintenance ensures the LFPI device functions reliably.
Properly maintained devices yield reproducible injury characteristics and severity.
This protocol addresses variability in TBI induction by standardizing device upkeep.

Conclusions:

Standardized maintenance protocols are vital for the LFPI model's reproducibility.
Adherence to these procedures enhances the validity of TBI research using LFPI.
This guide facilitates consistent application of the LFPI model for studying TBI mechanisms.