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Related Concept Videos

Sleep Apnea01:21

Sleep Apnea

202
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
202
Regulation of Stroke Volume01:27

Regulation of Stroke Volume

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The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
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Related Experiment Video

Updated: Jul 31, 2025

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model
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Causal Relations Between Obstructive Sleep Apnea and Stroke: A Mendelian Randomization Study.

Po Li1, Zhiyong Dong2, Wenhui Chen2

  • 1Department of General Surgery, Second People's Hospital of Zhangye City, Zhangye, 734000, People's Republic of China.

Nature and Science of Sleep
|May 8, 2023
PubMed
Summary
This summary is machine-generated.

Obstructive sleep apnea (OSA) does not appear to causally increase the risk of stroke or its subtypes, according to this Mendelian randomization study. Further research is needed to fully understand the complex relationship between OSA and cerebrovascular events.

Keywords:
Mendelian randomizationcausal associationobstructive sleep apneastroke

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Area of Science:

  • Neurology
  • Genetics
  • Epidemiology

Background:

  • Obstructive sleep apnea (OSA) is increasingly recognized, but its causal link to stroke remains unclear.
  • Previous epidemiological studies suggest an association, necessitating robust investigation into causality.

Purpose of the Study:

  • To investigate the potential causal effect of obstructive sleep apnea (OSA) on the risk of stroke and its specific subtypes.
  • Employing a two-sample Mendelian randomization approach to leverage genetic data for causal inference.

Main Methods:

  • Utilized a two-sample Mendelian randomization (MR) design, analyzing publicly available genome-wide association study (GWAS) data.
  • Applied the inverse variance weighted (IVW) method as the primary analysis, with MR-Egger, weighted median, and MR-PRESSO as supplementary analyses for robustness.

Main Results:

  • Genetically predicted OSA showed no significant causal association with overall stroke risk (OR, 0.99; P=0.909).
  • No causal link was observed for OSA with ischemic stroke, large vessel stroke, cardioembolic stroke, small vessel stroke, lacunar stroke, or intracerebral hemorrhage.
  • Consistent findings were confirmed across all supplementary MR methods, reinforcing the primary analysis results.

Conclusions:

  • The study suggests a lack of direct causal relationship between obstructive sleep apnea and the incidence of stroke or its major subtypes.
  • These findings contribute to understanding the etiological pathways of stroke and may inform clinical risk assessment.