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Metastatic HER2-amplified non-small-cell lung cancer treated with trastuzumab deruxtecan

Karen M Yun1, Lyudmila Bazhenova2

  • 1Division of Hematology-Oncology, Moores Cancer Center at UC San Diego Health, La Jolla, California, USA k5yun@health.ucsd.edu.

BMJ Case Reports
|May 8, 2023
PubMed

Insights

Trastuzumab deruxtecan shows promise for HER2-amplified non-small-cell lung cancer. This case study reports a durable response in a patient with metastatic HER2-amplified NSCLC, suggesting potential for this treatment.

Area of Science:

  • Oncology
  • Medical Genetics
  • Pharmacology

Background:

  • Human epidermal growth factor receptor 2 (HER2) alterations, including gene mutations, amplification, and protein overexpression, are implicated in various cancers.
  • Trastuzumab deruxtecan has shown efficacy in HER2-mutated non-small-cell lung cancer (NSCLC) in prior studies (DESTINY-Lung01 and DESTINY-Lung02).
  • The efficacy of trastuzumab deruxtecan in HER2-amplified NSCLC has not been previously investigated.
Keywords:
Lung cancer (oncology)Therapeutic indications

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