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Updated: Jul 31, 2025

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

The peritumor microenvironment: physics and immunity.

Sue Zhang¹, Kathryn Regan¹, Julian Najera²

¹Department of Biomedical Engineering, Boston University, Boston, MA, USA.

Trends in Cancer

|May 8, 2023

Summary

This summary is machine-generated.

The peritumor microenvironment has unique physical and immune properties that drive cancer progression. Understanding these features is crucial for developing new cancer therapies and overcoming immunotherapy resistance.

Keywords:

immunotherapy peritumor physical immunity physical oncology tumor microenvironment

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Area of Science:

Oncology
Cancer Biology
Immunology

Background:

Cancer progression significantly alters the tumor microenvironment.
The peritumor, the interface between healthy and malignant tissue, exhibits unique characteristics.
These characteristics involve interconnected mechanical signaling and immune activity.

Purpose of the Study:

To review the distinct physical features of the peritumoral microenvironment.
To link these physical features to immune responses within the tumor microenvironment.
To highlight the peritumor as a key area for cancer research and clinical applications.

Main Methods:

Literature review of studies on the peritumoral microenvironment.
Analysis of physical attributes of the peritumor.
Correlation of physical features with immune responses.
Identification of biomarkers and therapeutic targets in the peritumor.

Main Results:

The peritumor possesses unique physical and immune attributes.
These attributes promote tumor progression via mechanical signaling and immune activity.
The peritumor is rich in biomarkers and therapeutic targets.

Conclusions:

The peritumor microenvironment plays a critical role in cancer progression.
Understanding the peritumor is essential for developing novel cancer therapies.
Targeting the peritumor may help overcome immunotherapy resistance.