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Updated: Jul 31, 2025

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
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Published on: December 9, 2015

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Insight into the Basic Mechanisms and Various Modulation Strategies Involved in Cancer Drug Resistance

Devdhar Yadav1, Gudhanti Siva Naga Koteswara Rao1,2, Deepika Paliwal1

  • 1Department of Pharmacy, School of Medical & Allied Science, Galgotias University, Greater Noida, Uttar Pradesh, India.

Current Cancer Drug Targets
|May 9, 2023
PubMed

Insights

Tumor drug resistance is a growing problem. This review examines factors driving resistance, genetic changes, and strategies to overcome it in leukemia, ovarian, and breast cancers.

Area of Science:

  • Oncology
  • Pharmacology
  • Molecular Biology

Background:

  • Tumor drug resistance is an increasing clinical challenge.
  • Understanding resistance mechanisms is crucial for developing effective cancer therapies.

Conclusions:

  • Drug resistance is multifactorial, involving cellular and molecular mechanisms.
  • Targeting these mechanisms and exploring novel therapies are essential.
  • Management strategies are needed to overcome resistance in various cancers.
Keywords:
Cancerapoptosisbreast cancerdrug resistanceepigenetic/genetic determinantsleukaemiaovarian cancer

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