[Plasma fibronectin level in newborn infants with suppurative inflammatory diseases]

The level of plasma fibronectin was determined in healthy newborns (45 plasma samples were examined in the control group) and in newborns with pyo-septic diseases (67 plasma samples were examined) by the immunoenzyme method (on the basis of the "sandwich" modification of the immunoenzyme analysis). Noticeable hypofibrinectinemia was observed in the infants with pyo-inflammatory diseases, particularly in cases of generalized forms. Combined modality etiopathogenetic therapy including i.v. plasma transfusion, did not exceed fibronectin deficiency in clinical convalescence of infants. Fibronectin deficiency is regarded as a risk factor of the development and generalization of pyo-inflammatory diseases.