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Multiplex Chemical Imaging Based on Broadband Stimulated Raman Scattering Microscopy

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Multi-objective optimization of custom compound prism arrays for multiplexed optical imaging.

Liam J Price, Julia Tatz, Jason Sutin

|May 9, 2023

Summary

We developed new software to design compound prism arrays, enabling high-quality, customized chromatic dispersion for advanced optical instruments. This tool overcomes computational challenges, facilitating wider use of these powerful optical components.

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Area of Science:

Optics and Photonics
Computational Design
Spectroscopy

Background:

Compound prism arrays offer superior chromatic dispersion and high transmission compared to conventional prisms and gratings.
Designing these arrays is computationally complex, limiting their practical application.
Existing optical design tools lack the specificity for complex prism array optimization.

Purpose of the Study:

To introduce user-friendly software for designing compound prism arrays.
To enable high-speed optimization based on specific chromatic dispersion and detector geometry requirements.
To overcome the computational barriers in designing custom prism arrays.

Main Methods:

Developed customizable prism designer software utilizing information theory.
Implemented high-speed optimization algorithms guided by user-defined target specifications.
Simulated various prism array designs by modifying target parameters through user input.

Main Results:

Demonstrated the software's capability to design prism arrays for multiplexed, hyperspectral microscopy.
Achieved chromatic dispersion linearity and 70-90% light transmission in the visible spectrum (500-820 nm).
Validated the software's efficiency in simulating a wide range of prism array designs.

Conclusions:

The customizable prism designer software significantly simplifies the creation of advanced optical systems.
This tool enhances the adoption of compound prism arrays in photon-starved applications requiring high transmission and custom dispersion.
The software is adaptable for diverse optical spectroscopy and spectral microscopy applications with specific design needs.