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Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
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HDL-cholesterol concentration and its association with coronary artery calcification: a systematic review and

Farshad Abedi1, Masoumeh Sadeghi2, Navid Omidkhoda1

  • 1Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Lipids in Health and Disease
|May 9, 2023
PubMed

Insights

High-density lipoprotein cholesterol (HDL-C) levels do not appear to protect against coronary artery calcification (CAC). This suggests HDL particle quality, not just quantity, may be crucial for preventing atherosclerosis.

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Epidemiology

Background:

  • Coronary artery calcification (CAC) is a sensitive marker for coronary atherosclerosis.
  • The relationship between high-density lipoprotein cholesterol (HDL-C) and CAC development is debated.
  • Existing research presents conflicting findings on HDL-C's role in CAC progression.

Conclusions:

  • This meta-analysis of observational data indicates that elevated HDL-C levels do not predict protection against coronary artery calcification.
  • The findings suggest that the quality of HDL particles, rather than their concentration, may be more critical in atherogenesis and CAC development.
  • Further research should focus on the functional aspects of HDL in cardiovascular health.
Abstract

Keywords:
CAC, calcium scoreCoronary artery calcificationHDL function, meta-analysisHDL-CHigh-density lipoprotein-cholesterol

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