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Migrasomes, a new mode of intercellular communication
Yuyun Jiang1, Xi Liu1, Jixian Ye1
1Department of Central Laboratory, The Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, China.
Cell Communication and Signaling : CCS
|May 9, 2023
Summary
Migrasomes, novel extracellular vesicles (EVs) from migrating cells, uniquely mediate intercellular communication and are implicated in diverse pathological processes. Their distinct characteristics offer potential for disease diagnosis and therapeutic strategies.
Area of Science:
- Cell Biology
- Extracellular Vesicles
- Intercellular Communication
Background:
- Migrasomes are newly identified extracellular vesicles (EVs) originating from migrating cells, distinct from other EVs in size, formation, and cargo.
- They play roles in organogenesis, cellular waste removal (damaged mitochondria), and molecular transport (mRNA, proteins).
Discussion:
- Migrasomes are increasingly recognized for their involvement in various pathological processes.
- Specific examples include osteoclast differentiation, proliferative vitreoretinopathy, tumor metastasis (PD-L1 transport), immune cell chemotaxis, angiogenesis promotion, and leukemic cell homing.
Key Insights:
- Migrasomes exhibit unique biological generation, cargo packaging, and intercellular communication mechanisms compared to conventional EVs.
- Evidence highlights their significant role in both physiological processes and a spectrum of diseases.
Outlook:
- The distinct nature of migrasomes suggests their potential as biomarkers for disease diagnosis.
- Further research into migrasome biology could unveil novel therapeutic targets and strategies.
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