Renal and hepatic interactions between 2-hexanone and carbon tetrachloride in F-344 rats

Fisher-344 rats were pretreated with 2-hexanone (HX) and challenged with carbon tetrachloride (CCl4) in a replicated 3 X 4 factorial experiment to determine if HX potentiated CCL4-induced renal and hepatic damage. Rats given both HX and CCl4 demonstrated more severe hepatic injury at 24 and 48 h than did controls. However, in contrast to our experience with chloroform (CHCl3), CCl4-induced renal injury in HX-pretreated rats was only slightly greater than in vehicle-pretreated controls.