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Primary Spinal Infections in Patients With Hematologic Immunocompromising Conditions: A Systematic Literature Review.
Naomie Devico Marciano1, Ryan S Beyer, Andrew Nguyen
1From the University of California, Irvine School of Medicine, Irvine, CL, (Ms. Devico Marciano and Ms. Paladugu); the Department of Orthopaedic Surgery, University of California, Irvine, CL, (Mr. Beyer, Mr. Hatter, Mr. Franklin, Dr. Willhuber, Dr. Bhatia, and Dr. Lee); and the Department of Neurological Surgery, University of California, Irvine, CL, (Mr. Nguyen, Mr. Brown, and Dr. Oh).
Primary spinal infections (PSIs) in patients with hematologic disease are aggressive, leading to higher rates of neurologic deficits and complications. Early diagnosis and intervention are crucial for better outcomes in these vulnerable patients.
Area of Science:
- Infectious Diseases
- Hematology
- Spinal Surgery
Background:
- Primary spinal infections (PSIs) involve inflammation of the spinal cord's end plate-disk unit.
- PSIs are more aggressive in immunocompromised individuals, including those with hematologic diseases.
- The link between PSIs, cancer, and hemoglobinopathies requires systematic analysis.
Conclusions:
- Primary spinal infections in patients with hematologic disease show shorter diagnosis times but higher rates of neurologic deficit and surgical intervention.
- These infections present increased complication rates compared to the general population.
- Findings highlight the aggressive nature of PSIs in immunocompromised hematologic patients.
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