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Related Experiment Videos

Acute myocardial and plasma catecholamine changes in experimental stroke.

V C Hachinski, K E Smith, M D Silver

    Stroke
    |May 1, 1986
    PubMed
    Summary

    Focal cerebral ischemia in cats can lead to myocardial damage and increased norepinephrine and epinephrine levels. This suggests that elevated catecholamines following brain injury may harm the heart.

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    Area of Science:

    • Neuroscience
    • Cardiology
    • Pathophysiology

    Background:

    • Focal cerebral ischemia in humans correlates with cardiac arrhythmias and elevated cardiac enzymes.
    • Systemic catecholamine administration is known to induce myocardial damage.
    • This suggests a potential link between cerebral ischemia, elevated norepinephrine, and cardiac injury.

    Purpose of the Study:

    • To investigate the effects of middle cerebral artery occlusion on myocardial tissue and plasma catecholamine levels in cats.
    • To determine if cerebral ischemia triggers myocardial damage via increased sympathetic activity.

    Main Methods:

    • 23 cats were subjected to occlusion or sham occlusion of the middle cerebral artery under anesthesia and artificial ventilation.
    • Myocardial tissue and plasma catecholamine (norepinephrine and epinephrine) levels were monitored.

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  • Changes were assessed after 12-22 hours of occlusion.

    • Main Results:

    • 41% of cats with middle cerebral artery occlusion developed myocardial damage, including necrosis and hemorrhage.
    • Cats with myocardial damage showed significant increases in plasma norepinephrine and epinephrine levels.
    • Sham-occluded animals and those without myocardial damage did not exhibit significant changes in catecholamine levels.

    Conclusions:

    • Middle cerebral artery occlusion can induce myocardial damage in a subset of animals.
    • Elevated plasma catecholamine levels, particularly norepinephrine and epinephrine, are associated with this myocardial damage.
    • Increased sympathetic activity following cerebral ischemia may be the mechanism causing catecholamine-induced myocardial injury.