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Circulating endothelial cells fail to induce cerebral infarction in rabbits
Stroke
|May 1, 1986
Summary
Increased circulating endothelial cells do not cause cerebral embolism. Studies show injected endothelial cells, even when treated, failed to induce embolism in rabbits, suggesting other factors are involved.
Area of Science:
- Vascular biology
- Cerebrovascular research
- Hematology
Background:
- Exfoliated circulating endothelial cells (CECs) are detected in human blood.
- Endothelial cells are larger than other blood cells, raising questions about their role in embolism.
Purpose of the Study:
- To investigate if an increased number of CECs can cause cerebral embolism.
- To determine the potential of injected endothelial cells to induce cerebrovascular events.
Main Methods:
- Rabbits received injections of endothelial cell suspensions via the common carotid artery.
- Control rabbits were administered blood clots or arachidonic acid.
- Endothelial cell suspensions were also treated with ultrasonic waves before injection.
Main Results:
- Injected endothelial cells did not cause cerebral embolism in rabbits.
- Ultrasonically treated endothelial cell suspensions also failed to induce cerebral embolism.
- Degenerated and deformed CECs were observed in the injected suspensions.
Conclusions:
- An increased number of circulating endothelial cells alone is insufficient to induce cerebral embolism.
- The physical state and origin of circulating endothelial cells may influence their embolic potential.