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Impaired Morphological and Functional Maturation of the Spleen during Puberty in Rats Exposed to Low Doses of Endocrine Disruptor DDT.

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Changes in Secretion of the Thyroid and Pituitary Glands with a Gradual Decrease in Deuterium Body Content.

N V Yaglova1, S S Obernikhin2, E P Timokhina2

  • 1Laboratory of Endocrine System Development, A. P. Avtsyn Research Institute of Human Morphology, , A. P. Petrovsky Russian Research Center of Surgery, Moscow, Russia. yaglova@mail.ru.

Bulletin of Experimental Biology and Medicine
|May 9, 2023
PubMed
Summary
This summary is machine-generated.

Reducing deuterium in drinking water initially boosts thyroid hormones in rats. However, prolonged exposure leads to secondary hypothyroidism, with the thyroid gland showing faster adaptation than the pituitary.

Keywords:
deuteriumpituitarythyroidthyroid hormones

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Area of Science:

  • Endocrinology
  • Physiology
  • Biochemistry

Background:

  • Deuterium is a stable isotope of hydrogen.
  • Deuterium-depleted water (DDW) has shown various biological effects.
  • The impact of deuterium depletion on the thyroid-pituitary axis requires further investigation.

Purpose of the Study:

  • To investigate the effects of gradual deuterium depletion on thyroid hormone and TSH secretion in male Wistar rats.
  • To determine the sensitivity and response patterns of the thyroid gland and the hypothalamic-pituitary complex to reduced deuterium levels.

Main Methods:

  • Male Wistar rats were provided with deuterium-depleted water (10 ppm [D]) for 21 days.
  • Thyroid hormone and TSH levels were monitored throughout the study period.
  • Changes in secretion patterns were analyzed to assess the response of the endocrine system.

Main Results:

  • An increase in thyroid hormone secretion was observed as early as day 1 of DDW intake.
  • By day 14, a decrease in TSH secretion led to secondary hypothyroidism.
  • By day 21, thyroid hormone secretion normalized, and the thyroid hormone-TSH feedback loop was restored.

Conclusions:

  • The thyroid gland exhibits higher sensitivity to deuterium depletion than the hypothalamic-pituitary complex.
  • The thyroid gland's response involves activation of secretory processes, while the pituitary shows a transient decrease in secretory activity.
  • These findings highlight the distinct adaptive mechanisms of the thyroid and pituitary in response to altered deuterium levels.